With the preseason underway, preparations for the new NFL season are entering a critical phase. What’s the latest on injuries? Here’s the latest injury update.

Injuries are a daily occurrence in the NFL. Time and again, star players suffer injuries—unfortunately, sometimes serious ones.

What’s the current status during the preseason? Which players are injured? When will they return?

September, 8:35 p.m.: Sam Okuayinonu will miss the first few weeks of the season

The San Francisco 49ers have placed defensive end Sam Okuayinonu on the IR list due to a foot injury.

On Saturday, the franchise not only announced that he will miss the season opener against the Los Angeles Rams, but also signed Khalid Kareem from the Atlanta Falcons’ practice squad to fill the void.

Okuayinonu is expected to miss the 49ers’ first four games. Over the past two years, he has played in a total of 31 games, recording 74 tackles and six sacks.

September, 6:11 a.m.: Nick Bosa Practices for the First Time Since His ACL Tear

Nick Bosa missed nearly the entire previous season with a torn ACL.

However, the defensive end’s ordeal now appears to be over. As the San Francisco 49ers announced, Bosa practiced with the team without restrictions for the first time on Wednesday.

However, even during the media session following the practice, he left open the question of whether—and to what extent—he would be able to play against the Los Angeles Rams on Week 1 in Australia.

September 2, 6:23 a.m.: Lions Place Super Bowl Champion on IR

The Detroit Lions are dealing with a setback at the running back position: Isiah Pacheco has been placed on the Injured Reserve list.

The reason is a back injury that appears to be more serious than initially thought. Pacheco was supposed to form the new backfield duo with Jahmyr Gibbs as the successor to David Montgomery.

Pacheco cannot be activated until Week 5 at the earliest.

August 26, 5:30 p.m.: Torn ACL! Season over for Giants receiver

Bitter news for the New York Giants. Wide receiver Calvin Austin has suffered a torn ACL and is out for the 2026 season.

The wideout had to be carted off the field during a practice on Tuesday after injuring himself without contact from a teammate.

Austin had just signed a one-year contract in the Big Apple during the offseason.

August 26, 4:15 p.m.: Injury scare for Bucs rookie

Rueben Bain Jr., a rookie pass-rusher for the Tampa Bay Buccaneers, has suffered a sprained shoulder. According to “ESPN,” however, it is “nothing serious,” so playing in Week 1 is a realistic possibility.

Bain, who was selected 15th overall in the draft, was injured on Tuesday during a joint practice with the Jacksonville Jaguars.

August 26, 6:14 a.m.: Chase scare at Bengals practice

There was a brief moment of concern during the Cincinnati Bengals’ practice on Tuesday.

After attempting a catch, wide receiver Ja’Marr Chase injured his knee and was unable to get up for several moments. Fans and teammates were visibly concerned. Although Chase was able to leave the field on his own, continuing the practice session was out of the question for him.

Later, however, the all-clear was given. It was a mild knee hyperextension, the wide receiver himself said. There is currently no risk to his availability for the season opener.